Endocrine Abstracts

Fine needle aspiration is used extensively in the diagnostic evaluation of thyroid nodules. However, its diagnostic efficacy may be reduced by non-diagnostic findings. The aim was to study the effect of nodule size on the diagnostic efficacy of ultrasound-guided fine needle aspiration biopsy in thyroid nodules.Ultrasound-guided fine needle aspiration biopsy was performed in 210 patients with thyroid nodules. Cytology results were compared to nodule size....

Ultrasound-guided fine needle aspiration biopsy is used extensively in the diagnostic evaluation of thyroid nodules. However, its diagnostic efficacy is hampered by the presence of non-diagnostic cytology results.The aim was to study the effect of previous thyroxine suppression therapy on the diagnostic efficacy of fine needle aspiration biopsy in thyroid nodules.Ultrasound-guided aspiration biopsy was performed in 45 patients, 31 ...

BackgroundRecent data have shown the anti-apoptotic effect of Chchd2 mitochondrial protein through the Bcl-2/Bax pathway in various cancers. Bax is regulated primarily by proteins-members of Bcl-2 family and mainly the Bcl-2 protein, which has been found to prevent Bax from accumulating in mitochondria. In response to apoptotic stimuli, Chchd2 decreases and loses its mitochondria localization accompanying by decreased Bcl-2/Bax interaction and increased ...

Background: Follicle stimulating hormone (FSH), a dimeric glycoprotein hormone, stimulates Sertoli cell proliferation and spermatogenesis in males. Azoospermia is defined as the absence of sperm in the ejaculate. The majority of patients with non-obstructive azoospermia have high FSH levels. Isolated FSH deficiency has been reported in a few patients.Case Presentation: A 22-yr-old, 172-cm-tall male presented with azoospermia. He was born at full term wit...

Background: Primary thyroid lymphoma (PTL) is a rare thyroid malignancy. Nevertheless, it frequently presents diagnostic and therapeutic challenges. We describe two patients with PTL with different clinical presentation/clinical picture and outcome.Patients and methods: Two female patients underwent total thyroidectomy, the first, a 67-year-old female patient, because of nodular goitre and the second, a 79-year-old female patient, because of a large, pai...

Introduction: Despite the fact that CS is widely employed, further investigation on the topic of the physiology vis a vis this type of delivery is required, especially regardingstress related hormonal response during this practice. The aim of this study is to provide data regarding stress related hormonal response during Vaginal Delivery (VD) and elective CS evaluating levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1).<p...

Nonalcoholic fatty liver disease has an increased worldwide prevalence due to obesity and the use of various drugs affecting the liver. The pathogenesis of nonalcoholic fatty liver disease is presently not completely defined. In addition, there is a paucity of agents for its treatment. Choline deficiency has been shown to induce nonalcoholic liver disease. Systemic autoimmune rheumatic diseases require chronic systemic treatment with various agents, which may affect liver func...

Background: Low-grade systemic chronic inflammation has been recognized in diabetes. The purpose of this study was the assessment of proinflammatory cytokines secretion profile in long-standing diabetes along with the presence of systemic inflammation.Methods: Twenty patients with type 1 (T1DM: 7 women, age (±S.E.M.): 30.90±1.93 years, duration of disease: 142.47±28.34 months) and 21 patients with type 2 diabetes mellitus T2...

Introduction: Patients diagnosed with DTC have excellent prognosis. A small percentage of patients with disease persistence do not respond to treatment with RAI (RAI-refractory DTC) and have low median survival (3.5 years). We investigated the prognostic factors and the disease course in patients with RAI-refractory DTC.Methods: Of all DTC patients (n=1160) followed-up in our department in recent years, 800 received RAI treatment and were classified in 2...

Objectives: Medullary thyroid carcinoma (MTC) has varying clinical course with familial cases (fMTC) diagnosed earlier than sporadic ones (sMTC). We examined the presentation of these entities in our centre.Methods: 223 MTC patients (familial: 42.6%, males: 36.8%) were followed for 0.9–30 years (mean 6.23±5.9, median 4.0 years). 44 (19.7%) fMTC patients were operated after genetic screening.Results: Median age at diagnosi...